Substance use disorder (SUD) represents a large and growing global health problem.Despite the strong addictive potency of drugs of abuse, only a minority of those exposed develop SUDs.While certain life experiences (e.g., childhood trauma) may increase subsequent vulnerability to SUDs, mechanisms underlying these effects are not yet well understood
Chronic kidney disease (CKD) is a global public health problem, seemingly affecting individuals from low-income and-middle-income countries (LMICs) disproportionately, especially in sub-Saharan Africa.Despite Butter Knives the growing evidence pointing to an increasing prevalence of CKD across Africa, there has not been an Africa-wide concerted eff
The Aeolus satellite, the first spaceborne wind lidar launched by the European Space Agency (ESA) on 22 August 2018, provides global measurements of horizontal line-of-sight (HLOS) winds.The assimilation of Aeolus HLOS Amolador Facas winds has been proven to improve numerical weather predictions (NWPs).Still, its influences on forecasts of tropical
In many aspects of modern engineering (processes, products, and systems)InIn many aspects of modern engineering (processes, products, and systems) there is a Beauty Mirror need to optimize multiple responses simultaneously, rather than optimizing one response at a time.The optimization of each individual response may generate as many different resu
Seven of the most frequent spinocerebellar ataxias (SCAs) are caused by a pathological expansion of a cytosine, adenine and guanine (CAG) trinucleotide repeat located in exonic regions of unrelated genes, which in turn leads to the synthesis of polyglutamine (polyQ) proteins.PolyQ proteins are prone to aggregate and form intracellular inclusions, w